I can't believe no one has mentioned my second favorite guitar duo, which also blows yours out of the water.

They are certainly quick.

Ivy & Brian Gregory

Brian Baker, Greg Hetson, Brad Gurewitz of Bad Religion

Rodrigo y Gabriela

Link...

Clapton and Allman. Not a band exactly. But a historic meeting/union nonetheless...

Rodrigo y Gabriela

Really??? I respect their technique and gave it a try several times in the last few years but to me this is some of the most boring stuff ever. It lacks everything I like in music. I don't hate it. It just does nothing to me.

Clapton and Allman. Not a band exactly. But a historic meeting/union nonetheless...

Listening to the Layla album again recently I was struck by just how much lead Clapton let Allman play. Most songs he takes the spotlight. When Eric finally gets fired up in Have You Ever Loved a Woman it's noticeable that he goes to another level, though. There must have been some very strange things going on in this man's psyche at this time (heroin+Patty denials+Jimi+Jimi dying+denying hero status+the impact of The Band+who knows what else). At least it resulted in some transcendent tracks. I guess it doesn't matter as much who played what as much as the fact we have it at all.

I believe both of them were living at the extreme raw outer edge of their lives and their time. They seemed to recognize each other's deepest layer of angst and possibility in the music that Clapton was attempting to create with Layla. In Duane he obviously found a conduit to a level of creativity he had never achieved before. And vice versa. Two men lost in the darkness, leading each other back to the light. An incredible statement for both of them...

Marty and Kenny!

troy6120 was going for the metal. In that spirit I will say James Hetfield and Kirk Hammet.

Here are some others to go with the great ones already mentioned:

Billy Idol and Steve Stevens

Slash and Izzy Stradlin

Lenny Kravitz and Slash (Lenny's song "Always on the Run")

Steve Clark and Pete Willis (early Def Leppard)

Steve Clark and Phil Collen (middle Def Leppard)

Rossi & Parfitt

My vote goes for John Jorgensen, Will Ray and Jerry Donahue.

Inspector Gadget

(Strikes head with open palm, three days after first posting)!!!

Bert Jansch and John Renbourne

Joe Maphis & Larry Collins

hey Spike , thanks ,, i never even heard of Larry Collins ( how was that possible ) anyway this is great

Did anyone mention Robert Fripp and Adrian Belew? An odd couple. Wild and crazy over tidy buttoned-down.

Joe Walsh and Don Felder

Keef and Ronnie

David Hidalgo and Louis Perez and Cesar Rosa

Mike Campbell and Tom Petty

Allen Collins, Gary Rossington, Ed King

Keef and Ronnie ? Meh!

How about Keef and Brian or Keef and Mic Taylor

I can't believe no one has mentioned the powerhouse that was Glen Tipton and K.K.Downing.

I think that Mark Knopfler and Richard Thompson would be magical together!

Just remembered another one. I saw John McLaughlin and Carlos Santana on the "Love Devotion Surrender" tour, and thought McLaughlin's lightning articulation and exotic scales and Santana's lyricism both brought out the best in each other.

silverjetstaff, I'll call your Glen Tipton and K.K. Downing and raise you a Matthias Jabs and Rudolph Shenker.

Marty and Kenny!

Yep, they just "get it done"

Let's not forget a pair of "Southerners"....................Toy and Tommy Caldwell........The Marshall Tucker Band.

RIP Toy and Tommy, you guys kicked out some of the best over the years

Best guitar partnership..... David Gilmour and a Stratocaster

Rosewood and maple